Litcius/Paper detail

Evaluation of an ester-linked immunosuppressive payload: A case study in understanding the stability and cleavability of ester-containing ADC linkers

Courtney P. Jackson, Siteng Fang, Samantha R. Benjamin, Tchilabalo Dilezitoko Alayi, Yetrib Hathout, Sarah M. Gillen, Jillian P. Handel, Brittany M. Brems, Justin M. Howe, L. Nathan Tumey

2022Bioorganic & Medicinal Chemistry Letters11 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryCytosolInternalizationProdrugCatabolismBiochemistryCleaveCleavage (geology)LysosomeDeamidationEnzymeCellBiologyPaleontologyFracture (geology)Monoclonal and Polyclonal Antibodies ResearchHER2/EGFR in Cancer ResearchClick Chemistry and Applications