Carboxamide appended quinoline moieties as potential anti-proliferative agents, apoptotic inducers and Pim-1 kinase inhibitors
Yousry A. Ammar, Gamil A. M. Elhagali, Moustafa S. Abusaif, Mohamed R. Selim, Medhat A. Zahran, Tamer Naser, Ahmed B. M. Mehany, Eman A. Fayed
Topics & Concepts
ADMEChemistryIC50QuinolineApoptosisKinaseIn silicoDoxorubicinCell cultureCell growthCancer cellPharmacologyIn vitroBiochemistryCancerBiologyChemotherapyOrganic chemistryGeneticsGeneCancer Mechanisms and TherapySynthesis and biological activityPeptidase Inhibition and Analysis