Enzymatic assembly of the salinosporamide γ-lactam-β-lactone anticancer warhead
Katherine D. Bauman, Vikram V. Shende, Percival Yang-Ting Chen, Daniela Barretto Barbosa Trivella, Tobias A. M. Gulder, Sreekumar Vellalath, Daniel Romo, Bradley S. Moore
Topics & Concepts
WarheadEnzymeChemistryLactamLactoneBiochemistryBeta-lactamStereochemistryCombinatorial chemistryAntibioticsEngineeringAerospace engineeringCancer Research and TreatmentsEnzyme Structure and FunctionUbiquitin and proteasome pathways