Management of Patients with Epithelial Ovarian Cancer: A Systematic Comparison of International Guidelines from Scientific Societies (AIOM-BGCS-ESGO-ESMO-JGSO-NCCN-NICE)
Martina Arcieri, Veronica Tius, Sara Filippin, Giovanni Aletti, Domenica Lorusso, Anna Fagotti, Jalid Sehouli, Ignacio Zapardiel, Pierandrea De Iaco, Paolo Scollo, Andrea Ciavattini, Marco Petrillo, Violante Di Donato, Federica Perelli, Giorgio Bogani, Stefano Restaino, Giuseppe Vizzielli, the Gynecologic Oncology Group
Abstract
Epithelial ovarian cancer (EOC) remains the most lethal gynecological malignancy worldwide, primarily due to late-stage diagnosis, limited early screening tools, and the aggressive nature of the disease. Increasing global efforts have been directed toward harmonizing clinical guidelines and ensuring equitable access to optimal care. This narrative review provides a comprehensive overview and critical comparison of the most recent international guidelines for ovarian cancer management, emphasizing similarities and discrepancies. Each section examines diagnostic, surgical, and therapeutic recommendations across all disease stages-from prevention to recurrence. Emerging advances that are reshaping the management of EOC such as preclinical models and the application of artificial intelligence are also discussed. This work provides an updated and practical synthesis to support clinicians, researchers, and policymakers in optimizing ovarian cancer management and guiding future research priorities in precision oncology.