A thiol–ene click-based strategy to customize injectable polymer–nanoparticle hydrogel properties for therapeutic delivery
Sophia J. Bailey, Noah Eckman, Elisa S. Brunel, Carolyn K. Jons, Samya Sen, Eric A. Appel
Abstract
can be dramatically altered without sacrificing mesh size or cargo diffusion rates. This work offers a route to optimize PNP hydrogels for a variety of translational applications and holds promise in the highly tunable delivery of pharmaceuticals and adoptive cells.
Topics & Concepts
Self-healing hydrogelsClick chemistrySupramolecular chemistryNanoparticlePolymerEne reactionNanotechnologyMaterials scienceChemistryCombinatorial chemistryPolymer chemistryOrganic chemistryMoleculeHydrogels: synthesis, properties, applicationsSupramolecular Self-Assembly in MaterialsAdvanced Drug Delivery Systems