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Hsa_circ_0001869 promotes NSCLC progression via sponging miR-638 and enhancing FOSL2 expression

Pei Xu, Lei Wang, Xiao Xie, Fengqing Hu, Qi Yang, Rui Hu, Jiang Lianyong, Fangbao Ding, Ju Mei, Jianhui Liu, Haibo Xiao

2020Aging36 citationsDOIOpen Access PDF

Abstract

studies confirmed that overexpression of FOSL2 or silencing of miR-638 led to the recovery of tumor growth ability regarding A549 cells after hsa_circ_0001869 knockdown. Present investigation discovered that hsa_circ_0001869 enhanced NSCLC progression via sponging miR-638 and promoting FOSL2 expression. hsa_circ_0001869 downregulation suppressed tumor growth and invasion ability.

Topics & Concepts

Gene silencingDownregulation and upregulationGene knockdownCancer researchCell growthBiologyTumor progressionCell cultureCancerGeneGeneticsBiochemistryCircular RNAs in diseasesCancer-related molecular mechanisms researchMicroRNA in disease regulation
Hsa_circ_0001869 promotes NSCLC progression via sponging miR-638 and enhancing FOSL2 expression | Litcius