TGF-β1 promotes epithelial-to-mesenchymal transition and stemness of prostate cancer cells by inducing PCBP1 degradation and alternative splicing of CD44
Qi Chen, Meng Gu, Zhikang Cai, Hu Zhao, Shicheng Sun, Chong Liu, Ming Zhan, Yanbo Chen, Zhong Wang
Topics & Concepts
CD44Alternative splicingBiologyCancer stem cellEpithelial–mesenchymal transitionCancer researchGene knockdownRNA splicingStem cellProstate cancerRNA interferenceGene isoformCancer cellCell biologyCancerMolecular biologyCellMetastasisCell cultureRNAGeneGeneticsCancer-related molecular mechanisms researchRNA Research and SplicingRNA modifications and cancer