Computational assessment of MCM2 transcriptional expression and identification of the prognostic biomarker for human breast cancer
Abdus Samad, Farhana Haque, Zulkar Nain, Rahat Alam, Md Abdullah Al Noman, Mohammad Habibur Rahman Molla, Md Saddam Hossen, Md Raquibul Islam, Md. Iqbal Khan, Foysal Ahammad
Abstract
≤ 0.05) between the higher MCM2 expression and lower patient survival. Finally, we identified the co-expressed genes with gene ontological features and signaling pathways associated in BC development. We believe that this study will provide a basis for MCM2 to be a significant biomarker for human BC prognosis.
Topics & Concepts
BiologyMinichromosome maintenanceBreast cancerCancer researchGeneBiomarkerMutationCancerCell cycleDownregulation and upregulationMissense mutationGeneticsControl of chromosome duplicationCancer Genomics and DiagnosticsEpigenetics and DNA MethylationBioinformatics and Genomic Networks