Insights into the <scp>l</scp> , <scp>d</scp> -Transpeptidases and <scp>d</scp> , <scp>d</scp> -Carboxypeptidase of Mycobacterium abscessus: Ceftaroline, Imipenem, and Novel Diazabicyclooctane Inhibitors
Khalid M Dousa, Sebastian G. Kurz, Magdalena A. Taracila, Tracey L. Bonfield, Christopher R. Bethel, Melissa D. Barnes, Suresh B. Selvaraju, Ayman M. Abdelhamed, Barry N. Kreiswirth, W. Henry Boom, Shannon Kasperbauer, Charles L. Daley, Robert A. Bonomo
Abstract
Mycobacterium abscessus is a highly drug-resistant nontuberculous mycobacterium (NTM). Efforts to discover new treatments for M. abscessus infections are accelerating, with a focus on cell wall synthesis proteins ( M. abscessus l , d -transpeptidases 1 to 5 [Ldt Mab1 to Ldt Mab5 ] and d , d -carboxypeptidase) that are targeted by β-lactam antibiotics.
Topics & Concepts
ImipenemAvibactamMycobacterium abscessusMicrobiologyChemistryCephalosporinAntibioticsMycobacteriumBiochemistryBiologyBacteriaKlebsiella pneumoniaeAntibiotic resistanceGeneEscherichia coliGeneticsMycobacterium research and diagnosisQuinazolinone synthesis and applicationsTuberculosis Research and Epidemiology