Hepatitis B virus infection modeling using multi-cellular organoids derived from human induced pluripotent stem cells
Di Cao, Jian-Yun Ge, Yun Wang, Tatsuya Oda, Yun‐Wen Zheng
Abstract
modeling of intact human liver tissue, in terms of both hepatic function and other physiological characteristics. Combined with our experiences in the investigation of HBV infections using liver organoids, we have summarized the advances in modeling reported thus far and discussed the limitations and ongoing challenges in the application of liver organoids, particularly those with multi-cellular components derived from human iPSCs. This review provides general guidelines for establishing clinical-grade iPSC-derived multi-cellular organoids in modeling personalized hepatitis virus infection and other liver diseases, as well as drug testing and transplantation therapy.
Topics & Concepts
OrganoidInduced pluripotent stem cellVirologyBiologyStem cellHuman Induced Pluripotent Stem CellsHepatitis C virusVirusImmunologyMedicineCell biologyEmbryonic stem cellGeneticsGeneLiver physiology and pathologyPluripotent Stem Cells Research