Heartburn sensation in nonerosive reflux disease: pattern of superficial sensory nerves expressing TRPV1 and epithelial cells expressing ASIC3 receptors
Ahsen Ustaoglu, Akinari Sawada, Chung Lee, Wei‐Yi Lei, Chien‐Lin Chen, Richard Hackett, Daniel Sifrim, Madusha Peiris, Philip Woodland
Abstract
We demonstrate for the first time that increased pain perception in patients with nonerosive reflux disease likely results from expression of acid-sensitive channels on superficial mucosal afferents and esophageal epithelial cells, raising the potential for topical therapy.
Topics & Concepts
TRPV1RefluxSensory systemSensationHeartburnMedicineDiseaseReceptorInternal medicineGastroenterologyPsychologyTransient receptor potential channelNeuroscienceGastroesophageal reflux and treatmentsRespiratory and Cough-Related ResearchRefrigeration and Air Conditioning Technologies