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Piezo1 alleviates acetaminophen-induced acute liver injury by activating Nrf2 and reducing mitochondrial reactive oxygen species

Qimeng Wang, Xuyun Peng, Yifan Chen, Xiaoyan Tang, Yunfei Qin, Mian He, Wenjie Chen, Hui Chen, Hui Chen

2023Biochemical and Biophysical Research Communications24 citationsDOI

Topics & Concepts

Downregulation and upregulationPIEZO1AcetaminophenLiver injuryReactive oxygen speciesActivator (genetics)HepatocyteChemistryPharmacologyGene knockdownSOD2AntioxidantApoptosisMedicineMechanosensitive channelsBiochemistrySuperoxide dismutaseGeneIn vitroIon channelReceptorDrug-Induced Hepatotoxicity and ProtectionGenomics, phytochemicals, and oxidative stressLiver Disease Diagnosis and Treatment
Piezo1 alleviates acetaminophen-induced acute liver injury by activating Nrf2 and reducing mitochondrial reactive oxygen species | Litcius