Emodin attenuates cardiomyocyte pyroptosis in doxorubicin-induced cardiotoxicity by directly binding to GSDMD
Shanshan Dai, Yunxuan Chen, Xiaoxi Fan, Jibo Han, Lingfeng Zhong, Yucong Zhang, Qingran Liu, Jiahui Lin, Weijian Huang, Lan Su, Zhouqing Huang, Bozhi Ye, Bozhi Ye
Topics & Concepts
EmodinPyroptosisCardiotoxicityPharmacologyDoxorubicinChemistryMedicineCardiac function curveProgrammed cell deathToxicityBiochemistryApoptosisHeart failureInternal medicineChemotherapyChemotherapy-induced cardiotoxicity and mitigationCell death mechanisms and regulationChemotherapy-induced organ toxicity mitigation