Visible-light promoted α-alkylation of glycine derivatives with alkyl boronic acids
Jiayuan Wang, Yingpeng Su, Zheng‐Jun Quan, Jun Li, Jie Yang, Yong Yuan, Congde Huo
Abstract
A visible-light-mediated aerobic α-alkylation reaction of glycine derivatives with alkyl boronic acids has been established in the presence of a Ru/Cu catalyst system, giving the desired radical coupling products efficiently. The transformation features mild reaction conditions and broad substrate scope, delivering a wide range of complex unnatural α-amino-acid derivatives.
Topics & Concepts
AlkylationAlkylGlycineChemistryBoronic acidCombinatorial chemistryOrganic chemistryAmino acidCatalysisBiochemistryRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsOxidative Organic Chemistry Reactions