Nickel-Catalyzed Regioselective Hydroamination of Ynamides with Secondary Amines
Xiao-Di Nie, Xiaoli Han, Jian‐Ting Sun, Yuying Zhang, Bang‐Guo Wei, Guo‐Qiang Lin
Abstract
The first Ni(OTf)2-catalyzed hydroamination of ynamides 2 was developed by reacting with secondary amines (1 and 4). This protocol features excellent regioselectivity, a broad substrate scope of secondary aryl amines, and good functional group tolerance for ynamides. Using this method, a variety of substituted ethene-1,1-diamine compounds were prepared in moderate to excellent yields with high regioselectivities.
Topics & Concepts
HydroaminationRegioselectivityChemistryCatalysisArylSubstrate (aquarium)NickelCombinatorial chemistryDiamineFunctional groupOrganic chemistryPolymerOceanographyGeologyAlkylCatalytic Alkyne ReactionsCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions