Direct synthesis of indazole derivatives <i>via</i> Rh(<scp>iii</scp>)-catalyzed C–H activation of phthalazinones and allenes
Chuanliu Yin, Tianshuo Zhong, Xiangyun Zheng, Lianghao Li, Jian Zhou, Chuanming Yu
Abstract
An Rh( iii )-catalyzed annulation of phthalazinones and various allenes was developed, leading to the formation of indazole derivatives. This catalytic system exhibits excellent functional group tolerance and atom economy.
Topics & Concepts
ChemistryOlefin fiberIndazoleCatalysisIntramolecular forceAnnulationSelectivityCombinatorial chemistryFunctional groupMedicinal chemistryStereochemistryHydrideOrganic chemistryPolymerHydrogenCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisCatalytic Alkyne Reactions