Absence of MHC class II on cDC1 dendritic cells triggers fatal autoimmunity to a cross-presented self-antigen
Christian Wohn, Valentin Le Guen, Odessa Voluzan, Frédéric FIORE, Sandrine Henri, Bernard MALISSEN
Abstract
T cell effectors from the cutaneous draining lymph nodes abrogated the autoimmune condition. Therefore, our results revealed that the cross-tolerizing capacity of cDC1s is not a property fully acquired at the time they undergo homeostatic maturation but needs to be enforced via MHCII-restricted, suppressive interactions with regulatory T cells.
Topics & Concepts
BiologyCross-presentationAutoimmunityImmunologyEffectorCell biologyCD8AntigenMHC class IImmune systemT-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune Cell Function and Interaction