Immune synapse instructs epigenomic and transcriptomic functional reprogramming in dendritic cells
Ana Alcaraz‐Serna, Eugenio Bustos‐Morán, Irene Fernández‐Delgado, Diego Calzada‐Fraile, Daniel Torralba, Ester Marina-Zárate, Erika Lorenzo-Vivas, Enrique Vázquez, Juliana Barreto de Albuquerque, Nora Ruef, Manuel J. Gómez, Fátima Sánchez‐Cabo, Ana Dopazo, Jens V. Stein, Almudena R. Ramiro, Francisco Sánchez‐Madrid
Abstract
as a proof-of-concept gene that is increased in postsynaptic DCs. Consistent with our epigenomic observations, postsynaptic DCs migrate more efficiently toward CCL19 in vitro and display enhanced homing to draining lymph nodes in vivo. This work describes a previously unknown DC population whose transcriptomics, epigenomics, and migratory capacity change in response to their cognate contact with T cells.
Topics & Concepts
ReprogrammingEpigenomicsImmune systemTranscriptomeDendritic cellBiologyImmunological synapseSynapseInnate immune systemCell biologyComputational biologyNeuroscienceCellGeneticsT cellGeneDNA methylationGene expressionT-cell receptorImmunotherapy and Immune ResponsesImmune Cell Function and InteractionImmune responses and vaccinations