Metformin prevents morphine-induced apoptosis in rats with diabetic neuropathy: a possible mechanism for attenuating morphine tolerance
Onur Avcı, Ercan Özdemir, Ahmet Şevki Taşkıran, Zeynep Deniz Şahin İnan, Sinan Gürsoy
Topics & Concepts
MetforminMorphineNociceptionPharmacologyMedicineTUNEL assayApoptosisDiabetes mellitusDorsal root ganglionStreptozotocinNeuropathic painDiabetic neuropathyEndocrinologyInternal medicineChemistryReceptorImmunohistochemistryDorsumBiochemistryAnatomyPain Mechanisms and TreatmentsNeuroscience and Neuropharmacology ResearchNerve injury and regeneration