Recent Advances in Bioorthogonal Ligation and Bioconjugation
Florian Martin Zielke, Floris P. J. T. Rutjes
Abstract
The desire to create biomolecules modified with functionalities that go beyond nature's toolbox has resulted in the development of biocompatible and selective methodologies and reagents, each with different scope and limitations. In this overview, we highlight recent advances in the field of bioconjugation from 2016 to 2023. First, (metal-mediated) protein functionalization by exploiting the specific reactivity of amino acids will be discussed, followed by novel bioorthogonal reagents for bioconjugation of modified biomolecules.
Topics & Concepts
BioconjugationBioorthogonal chemistryChemistryBiomoleculeCombinatorial chemistryNanotechnologyToolboxBiocompatible materialPosttranslational modificationClick chemistryBiochemistryComputer scienceEnzymeBiomedical engineeringProgramming languageMaterials scienceMedicineClick Chemistry and ApplicationsPeptidase Inhibition and AnalysisChemical Synthesis and Analysis