SRC3 acetylates calmodulin in the mouse brain to regulate synaptic plasticity and fear learning
Hailong Zhang, Wei Han, Yin-Quan Du, Bing Zhao, Pin Yang, Dong‐Min Yin
Abstract
and NMDA receptor-dependent manner. We also show that pharmacological inhibition or genetic downregulation of SRC3 impairs CaM acetylation, synaptic plasticity, and contextual fear learning in mice. Moreover, the effects of SRC3 inhibition on synaptic plasticity and fear learning could be rescued by 3KQ-CaM, a mutant form of CaM, which mimics acetylation. Together, these observations demonstrate that SRC3 acetylates CaM and regulates synaptic plasticity and learning in mice.
Topics & Concepts
Synaptic plasticityNeuroscienceCalmodulinPlasticityPsychologyCell biologyChemistryBiologyCalciumMedicineBiochemistryMaterials scienceInternal medicineComposite materialReceptorNeuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersNeurogenesis and neuroplasticity mechanisms