Early life changes in histone landscape protect against age-associated amyloid toxicities through HSF-1-dependent regulation of lipid metabolism
Bryndon J. Oleson, Janakraj Bhattrai, Sarah L. Zalubas, Tessa R. Kravchenko, Yuanyuan Ji, Emily L. Jiang, Christine C. Lu, Ciara Madden, Julia G. Coffman, Daphne Bazopoulou, Jace W. Jones, Ursula Jakob
Topics & Concepts
ProteotoxicityCaenorhabditis elegansH3K4me3Lipid metabolismBiologyReactive oxygen speciesCell biologyAmyloid (mycology)Heat shock proteinEpigeneticsHistoneHSF1Hsp70BiochemistryProtein aggregationBotanyGene expressionGenePromoterGenetics, Aging, and Longevity in Model OrganismsCircadian rhythm and melatoninBirth, Development, and Health