Structure and Function of the Bestrophin family of calcium-activated chloride channels
Aaron P. Owji, Alec Kittredge, Yu Zhang, Tingting Yang
Abstract
(bovine Best2, bBest2). Meanwhile, whole-cell patch clamp, planar lipid bilayer, and other electrophysiologic analyses using these models as well as the human Best1 (hBest1) have provided ample evidence describing the functional properties of the bestrophin channels. This review seeks to consolidate these structural and functional results to paint a broad picture of the underlying mechanisms comprising the bestrophin family's structure-function relationship.
Topics & Concepts
GatingChloride channelLipid bilayerIon channelBiophysicsCalciumPatch clampChemistryBiologyElectrophysiologyCell biologyBiochemistryNeuroscienceReceptorMembraneOrganic chemistryLipid Membrane Structure and BehaviorNeuroscience and Neuropharmacology ResearchConnexins and lens biology