The role of CTHRC1 in promotion of cutaneous wound healing
Xianlan Duan, Xingyu Yuan, Bin Yao, Wei Song, Li Zhao, Enhejirigala, Yi Kong, Yuzhen Wang, Xiaobing Fu, Sha Huang
Abstract
Wound healing after tissue injury is a well-orchestrated process involving various cell types, growth factors, and extracellular matrix (ECM) components. Collagen triple helix repeat containing-1 (CTHRC1), a secreted ECM protein, is transiently expressed in the repair process after arterial injury and myocardial infarction, 1 regulating collagen matrix deposition and cell migration through TGF- signaling pathway. 2 However, the expression and function of CTHRC1 during cutaneous wound repair remain largely undefined.
Topics & Concepts
Wound healingMedicineDermatologyBioinformaticsBiologySurgeryWnt/β-catenin signaling in development and cancerCancer-related gene regulationCytokine Signaling Pathways and Interactions