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Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity

Zhu Huang, Robert Blum, Davide Bernareggi, Eivind Heggernes Ask, ZhengMing Wu, Hanna Julie Hoel, Zhipeng Meng, Chengsheng Wu, Kun‐Liang Guan, Karl‐Johan Malmberg, Dan S. Kaufman

2020Cell stem cell335 citationsDOIOpen Access PDF

Topics & Concepts

BiologyIn vivoPersistence (discontinuity)Cancer researchCISHCell biologyGeneticsGeneGene expressionIn situ hybridizationEngineeringGeotechnical engineeringImmune Cell Function and InteractionCAR-T cell therapy researchAdenosine and Purinergic Signaling