The uricosuric benzbromarone disturbs the mitochondrial redox homeostasis and activates the NRF2 signaling pathway in HepG2 cells
Noëmi Johanna Roos, Urs Duthaler, Jamal Bouitbir, Stephan Krähenbühl
Topics & Concepts
BenzbromaroneOxidative stressChemistryGCLCReactive oxygen speciesThioredoxinGlutathioneGCLMMitochondrionSOD2Superoxide dismutaseBiochemistryCell biologyBiologyUric acidHyperuricemiaEnzymeGenomics, phytochemicals, and oxidative stressGlutathione Transferases and PolymorphismsDrug-Induced Hepatotoxicity and Protection