Facile Synthesis of Xanthenesdiones and Acridinediones through TEMPO/CuCl<sub>2</sub> Catalyzed Aerobic Oxidation of Benzyl Alcohols and Cyclization with Cyclohexane-1,3-Dicarbonyl Compounds
Dalavai Pavithra, K. R. Ethiraj
Abstract
A series of xanthenediones, 3 were synthesized from benzyl alcohols, 1 via TEMPO/CuCl2 catalyzed aerobic oxidation, and sequential cyclization with cyclohexane-1,3-dicarbonyl compounds has been achieved. Similarly, the acridine-diones, 5 were obtained using a similar strategy from various benzyl alcohols. The strategy offers a simple experimental procedure, ease of access, within short reaction period, without the use of any hazardous solvents, and expensive chemicals.
Topics & Concepts
ChemistryCyclohexaneCatalysisOrganic chemistryAlcohol oxidationCombinatorial chemistryOxidative Organic Chemistry ReactionsAsymmetric Synthesis and CatalysisAlkaloids: synthesis and pharmacology