Protective effect of <scp>d</scp>-alanine against acute kidney injury
Yasunori Iwata, Yusuke Nakade, Shinji Kitajima, Shiori Nakagawa, Megumi Oshima, Norihiko Sakai, Hisayuki Ogura, Kōichi Sato, Tadashi Toyama, Yuta Yamamura, Taro Miyagawa, Hiroka Yamazaki, Akinori Hara, Miho Shimizu, Kengo Furuichi, Masashi Mita, Kenji Hamase, Tomohiro Tanaka, Motohiro Nishida, Wataru Muramatsu, Hisashi Yamamoto, Shigeyuki Shichino, Satoshi Ueha, Kouji Matsushima, Takashi Wada
Abstract
d-Alanine has protective effects on I/R-induced kidney injury. d-Ala inhibits ROS production and improves mitochondrial membrane potential, resulting in reduced TEC necrosis by hypoxic stimulation. The administration of d-Ala protects the tubules from I/R injury in mice. Moreover, the plasma level of d-Ala is conversely associated with eGFR in patients with AKI. Our data suggest that d-Ala is an appealing therapeutic target and a potential biomarker for AKI.