Lycopene attenuates <scp>d</scp>-galactose-induced insulin signaling impairment by enhancing mitochondrial function and suppressing the oxidative stress/inflammatory response in mouse kidneys and livers
Jia Wang, Ting Li, Mengling Li, Dongxing Shi, Xintong Tan, Fubin Qiu
Abstract
D-gal for 8 weeks and received 0.03% LYC (w/w, mixed into diet). The results showed that LYC ameliorated oxidative stress triggered by D-gal by enhancing the Nrf2 antioxidant defense pathway and increasing the expression of the antioxidant response genes HO-1 and NQO1 in mouse kidneys and livers. LYC inhibited the MAPK and NFκB pathways and attenuated renal and hepatic inflammatory responses. Moreover, LYC upregulated the expression of genes related to mitochondrial biosynthesis and oxidative phosphorylation and improved insulin signal transduction through the IRS-1/AKT/GSK3β pathway in mouse kidneys and livers.
Topics & Concepts
Oxidative stressAntioxidantProtein kinase BLycopeneSignal transductionMAPK/ERK pathwayChemistryReactive oxygen speciesDownregulation and upregulationEndocrinologyInternal medicineOxidative phosphorylationPharmacologyBiologyBiochemistryMedicineGeneAntioxidants, Aging, Portulaca oleraceaDiet, Metabolism, and DiseaseAdvanced Glycation End Products research