Design, Synthesis, and Evaluation of Extended C<sub>4</sub>–Symmetric Dirhodium Tetracarboxylate Catalysts
Zachary J. Garlets, Yannick T. Boni, Jack C. Sharland, Randall P. Kirby, Jiantao Fu, John Bacsa, Huw M. L. Davies
Abstract
The synthesis and evaluation of six C4-symmetric bowl-shaped dirhodium tetracarboxylate catalysts are described. These elaborate high-symmetry catalysts are readily generated by means of the self-assembly of four C1-symmetric ligands around the dirhodium core. These catalysts are capable of highly site-selective, diastereoselective, and enantioselective C–H functionalization reactions by means of donor/acceptor carbene-induced C–H insertions.
Topics & Concepts
CatalysisCarbeneEnantioselective synthesisChemistryAcceptorCombinatorial chemistryStereochemistryOrganic chemistryPhysicsCondensed matter physicsCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsAsymmetric Hydrogenation and Catalysis