Visible‐Light‐Driven Photocatalysis‐Enhanced Nanozyme of TiO<sub>2</sub> Nanotubes@MoS<sub>2</sub> Nanoflowers for Efficient Wound Healing Infected with Multidrug‐Resistant Bacteria
Yu Lin, Xiangyong Liu, Zengxu Liu, Yuanhong Xu
Abstract
Abstract To enhance the catalytic activity of the nanozymes for efficient wound healing infected with multidrug‐resistant bacteria, photo‐based motivations have been suggested, but attention is mainly focused on the external stimulus of near‐infrared light, while the inexhaustible visible one is promising but lack of study. Herein, an efficient visible light‐stimulated peroxidase‐like nanozyme system, TiO 2 nanotubes coated with MoS 2 nanoflowers (TiO 2 NTs@MoS 2 ), is discovered for efficient bacterial treatment. Based on the synergetic effects between the two components, the bandgap of the TiO 2 NTs can be narrowed from 3.2 to 2.97 eV due to the MoS 2 loading, which extended the light response of TiO 2 to visible‐light range and enhanced the photocatalytic activity accordingly. Meanwhile, the peroxidase‐like activity of MoS 2 can be significantly enhanced due to the combination with TiO 2 NTs in return. Especially, the peroxidase‐like activity of the TiO 2 NTs@MoS 2 nanocomposite can be further improved under the sunlight irradiation, rendering much more hydroxyl radical (•OH) generation. Accordingly, the as‐obtained TiO 2 NTs@MoS 2 shows an outstanding antibacterial effect against drug‐resistance extended spectrum β‐lactamases producing Escherichia coli and methicillin‐resistant Staphylococcus aureus under the visible light. In vivo wound healing test further confirms the high antimicrobial efficiency and good biocompatibility of the synergistic antimicrobial system.