3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis
Nobuaki Takahashi, Patricia Cho, Laura M. Selfors, Hendrik J. Kuiken, Roma Kaul, Takuro Fujiwara, Isaac S. Harris, Tian Zhang, Steven P. Gygi, Joan S. Brugge
Topics & Concepts
BiologyCRISPRSpheroidCell biologyComputational biologyGeneticsCell cultureGeneCancer Cells and MetastasisExtracellular vesicles in diseaseEpigenetics and DNA Methylation