Lymphangion-chip: a microphysiological system which supports co-culture and bidirectional signaling of lymphatic endothelial and muscle cells
Amirali Selahi, Teshan Fernando, Sanjukta Chakraborty, Mariappan Muthuchamy, David C. Zawieja, Abhishek Jain
Abstract
in the past. This system successfully characterizes the dynamics of cell size, density, growth, alignment, and intercellular gap due to co-culture and shear. Finally, exposure to pro-inflammatory cytokines reveals that the device could facilitate the regulation of endothelial barrier function through the lymphatic muscle cells. Therefore, this bioengineered platform is suitable for use in preclinical research of lymphatic and blood mechanobiology, inflammation, and translational outcomes.
Topics & Concepts
Lymphatic EndotheliumCell biologyLymphatic systemOrgan-on-a-chipChipChemistryNeuroscienceBiologyNanotechnologyEngineeringMaterials scienceTelecommunicationsImmunologyMicrofluidics3D Printing in Biomedical ResearchLymphatic System and DiseasesPlanarian Biology and Electrostimulation