Design, synthesis and biological evaluation of novel histone deacetylase1/2 (HDAC1/2) and cyclin-dependent Kinase2 (CDK2) dual inhibitors against malignant cancer
Fan Yun, Chunhui Cheng, Sadeeq Ullah, Qipeng Yuan
Topics & Concepts
ChemistryPharmacophoreHDAC1KinaseAcetylationCyclin-dependent kinase 2PharmacologyCyclin-dependent kinaseCancer researchHistone deacetylaseApoptosisStereochemistryCell cycleBiochemistryHistoneBiologyGeneHistone Deacetylase Inhibitors ResearchProtein Degradation and InhibitorsPeptidase Inhibition and Analysis