Computational evidence of glycosyl cations
Pedro Merino, Ignacio Delso, Sandra C. Pereira, Sara Orta, Manuel Pedrón, Tomás Tejero
Abstract
2-type glycosylation reaction mechanisms, but elucidation of mechanisms in which ion pairs can be formed presents some difficulties because of the recombination of the ions. Recent topological and dynamic studies open the door to the ultimate confirmation of the presence of glycosyl cations in the form of intimate ion pairs during certain glycosylation reactions. This review covers the state-of-the-art tools and applications of computational chemistry mainly developed during the last ten years to understand glycosylation reactions in which an oxocarbenium ion could be involved.
Topics & Concepts
GlycosylChemistryCombinatorial chemistryComputational chemistryOrganic chemistryCarbohydrate Chemistry and SynthesisGlycosylation and Glycoproteins ResearchChemical Synthesis and Analysis