Computer-aided directed evolution ofl-threonine aldolase for asymmetric biocatalytic synthesis of a chloramphenicol intermediate
Baoqin Cai, Marco Bocola, Ameng Zhou, Fenshuai Sun, Qing Xu, Jiadong Yang, Tianran Shen, Zhaoqi Zhang, Lei Sun, Yaoyao Ji, Yong Koy Bong, Thomas Daußmann, Haibin Chen
Topics & Concepts
ChemistryAldolase ADirected evolutionSelectivitySubstrate (aquarium)ThreonineCombinatorial chemistryStereochemistryAmino acidEnzymeOrganic chemistryBiochemistryCatalysisMutantSerineOceanographyGeneGeologyEnzyme Structure and FunctionAmino Acid Enzymes and MetabolismProtein Structure and Dynamics