Structure-based discovery of novel cruzain inhibitors with distinct trypanocidal activity profiles
Viviane Corrêa Santos, Paulo Gaio Leite, Lucianna Helene Santos, Pedro G. Pascutti, Peter Kolb, Fabiana S. Machado, Rafaela Salgado Ferreira
Topics & Concepts
Trypanosoma cruziChemistryChagas diseaseCysteine proteaseTrypanocidal agentDocking (animal)Drug discoveryIsoquinolinePharmacologyBiochemistryComputational biologyProteaseStereochemistryTrypanosoma bruceiBiologyEnzymeVirologyGeneNursingComputer scienceParasite hostingMedicineWorld Wide WebTrypanosoma species research and implicationsResearch on Leishmaniasis StudiesBioactive Compounds and Antitumor Agents