Reversible promoter demethylation of PDGFD confers gemcitabine resistance through STAT3 activation and RRM1 upregulation
Qin Li, Zizheng Dong, Caoqinglong Huang, Hao Liu, Jenny Beebe, Boopathi Subramaniyan, Yangyang Hao, Yunlong Liu, Zhimin He, Jingyuan Liu, Jian‐Ting Zhang
Topics & Concepts
GemcitabineDownregulation and upregulationCancer researchEpigeneticsAutocrine signallingBisulfite sequencingBiologyMethylationDNA methylationCancerMedicineInternal medicineGene expressionGeneCell cultureGeneticsEpigenetics and DNA MethylationPancreatic and Hepatic Oncology ResearchCancer-related gene regulation