<i>In Vivo</i> Targeting of Escherichia coli with Vancomycin-Arginine
Lewis F. Neville, Itamar Shalit, Peter Warn, Marc H. Scheetz, Jizhou Sun, Madeline B. Chosy, Paul A. Wender, Lynette Cegelski, Jacob T. Rendell
Abstract
The ability of vancomycin-arginine (V-r) to extend the spectrum of activity of glycopeptides to Gram-negative bacteria was investigated. Its MIC toward Escherichia coli , including β-lactamase expressing Ambler classes A, B, and D, was 8 to 16 μg/ml.
Topics & Concepts
Escherichia coliVancomycinGlycopeptideMicrobiologyArginineIn vivoEnterobacteriaceaeAntibioticsBacteriaEscherichiaBiologyChemistryBiochemistryAmino acidStaphylococcus aureusGeneticsGeneAntimicrobial Peptides and ActivitiesBacteriophages and microbial interactionsAntibiotic Resistance in Bacteria