Agglutination of Borreliella burgdorferi by Transmission-Blocking OspA Monoclonal Antibodies and Monovalent Fab Fragments
Amber M. Frye, Monir Ejemel, Lisa A. Cavacini, Yang Wang, M. Rudolph, Renjie Song, Nicholas J. Mantis
Abstract
Lyme disease vaccines based on recombinant O uter s urface p rotein A (OspA) elicit protective antibodies that interfere with tick-to-host transmission of the disease-causing spirochete Borreliella burgdorferi . Another hallmark of OspA antisera and certain OspA monoclonal antibodies (MAbs) is their capacity to induce B. burgdorferi agglutination in vitro , a phenomenon first reported more than 30 years ago but never studied in molecular detail.
Topics & Concepts
Borrelia burgdorferiMonoclonal antibodyVirologyBiologyLyme diseaseAgglutination (biology)AntibodyAntiserumRecombinant DNAMicrobiologySpirochaetaceaeImmunologyGeneticsGeneVector-borne infectious diseasesViral Infections and VectorsVector-Borne Animal Diseases