Copper-Catalyzed Regio- and Enantioselective Hydrosilylation of Internal Alkynes for Synthesis of Si-Stereogenic Vinylsilanes
Xiaoyan Zhu, Zilu Wang, Jian‐Lin Xu, Lei Xu, Xing Hu, Junwei Zhang, Yun‐He Xu
Abstract
Alkyne hydrosilylation is one of the most straightforward strategies for the synthesis of vinylsilanes, which have found extensive applications in synthetic chemistry. However, the regio- and enantioselective hydrosilylation of prochiral dihydrosilanes with unsymmetrical internal alkynes to construct silicon-stereogenic hydrosilanes poses significant challenges. This study presents a copper-catalyzed asymmetric hydrosilylation of internal alkynes and 1,3-diynes with dihydrosilanes that enables the synthesis of silicon-stereogenic vinylsilanes with high regio- and enantioselectivity. This methodology demonstrates broad substrate compatibility and provides facile access to chiral alkenylhydrosilanes via a simple Cu/( R, R )-Ph-BPE catalytic system.