Synthesis of <i>N</i>‐Sulfonyl Pyrazoles Through Cyclization Reactions of Sulfonyl Hydrazines with Enaminones Promoted by <i>p</i>‐TSA
Qiaohe Zhang, Biao Hu, Yuxuan Zhao, Siyun Zhao, Yanqin Wang, Biao Zhang, Sheng‐Jiao Yan, Fuchao Yu
Abstract
A strategy for the rapid synthesis of 3‐substituted N ‐sulfonyl pyrazoles via p ‐TSA‐promoted cyclization reactions of sulfonyl hydrazines with N , N ‐dimethyl enaminones has been developed. This method achieves both the formation of pyrazole ring and the continued retention of sulfonyl group, providing a series of 3‐substituted N ‐sulfonyl pyrazoles in moderate to good yields with good functional group tolerance, easily available starting materials, and can be scaled‐up.
Topics & Concepts
SulfonylChemistryPyrazoleRing (chemistry)Organic chemistryMedicinal chemistryCombinatorial chemistryAlkylSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms