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The discovery of novel and potent indazole NLRP3 inhibitors enabled by DNA-encoded library screening

George D. Hartman, Paul S. Humphries, Robert Hughes, Andrew Ho, Rusty L. Montgomery, Aditi Deshpande, Maitriyee Mahanta, Sarah U. Tronnes, Samantha Cowdin, Xu Jiang He, Fangchao Liu, Lifang Zhang, Chuan Liu, Dengfeng Dou, Jin Li, Aleksander Spasic, Rebecca C. Coll, Michael Marleaux, Inga V. Hochheiser, Matthias Geyer, Paul Rubin, Kristen Fortney, Kevin Wilhelmsen

2024Bioorganic & Medicinal Chemistry Letters16 citationsDOIOpen Access PDF

Topics & Concepts

IndazoleInflammasomeChemistryPyrin domainPyroptosisCaspase 1IntracellularLead compoundDrug discoveryBiochemistryComputational biologyCell biologyIn vitroReceptorStereochemistryBiologyInflammasome and immune disordersinterferon and immune responsesTryptophan and brain disorders
The discovery of novel and potent indazole NLRP3 inhibitors enabled by DNA-encoded library screening | Litcius