Photocatalytic chemo-, regio- & stereoselective olefinic β-C–H decarboxylative alkylation of enamides with diacyl peroxides
Han Liu, Yechun Wu, Lingli Liu, Jin‐Tao Yu, Changduo Pan
Abstract
A decarboxylative alkylation of enamides with alkyl diacyl peroxides induced by visible-light is described. The chemo-, regio- and stereoselective olefinic β-C-H alkylation generates a series of primary- and secondary alkylated enamides in yields up to 95%. This transformation bears the advantages of operational simplicity, good functional group compatibility and mild conditions.
Topics & Concepts
AlkylationStereoselectivityChemistryAlkylOrganic chemistryPhotocatalysisCatalysisRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques