Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold–small molecule interactions
Hafeez S. Haniff, Laurent Knerr, Xiaohui Liu, Gogce Crynen, Jonas Boström, Daniel Abegg, Alexander Adibekian, Elizabeth Lekah, Kye Won Wang, Michael D. Cameron, Ilyas Yildirim, Malin Lemurell, Matthew D. Disney
Topics & Concepts
Small moleculeRNAmicroRNAVascular endothelial growth factor AChemistryCell biologyAngiogenesisMessenger RNAVascular endothelial growth factorSmall RNATranscription factorComputational biologyBiologyBiochemistryCancer researchGeneVEGF receptorsRNA Research and SplicingRNA and protein synthesis mechanismsRNA modifications and cancer