The Great ESKAPE: Exploring the Crossroads of Bile and Antibiotic Resistance in Bacterial Pathogens
Kevin S. Gipson, Kourtney P. Nickerson, Eliana Drenkard, Alejandro Llanos‐Chea, Snaha Krishna Dogiparthi, Bernard B. Lanter, Rhianna M. Hibbler, Lael M. Yonker, Bryan P. Hurley, Christina S. Faherty
Abstract
(ESKAPE), and other enteric pathogens to resist bile and how these interactions can impact the sensitivity of bacteria to various antimicrobial agents. Given that pathogen exposure to bile is an essential component to gastrointestinal transit that cannot be avoided, understanding how bile resistance mechanisms align with antimicrobial resistance is vital to our ability to develop new, successful therapeutics in an age of widespread and increasing antimicrobial resistance.
Topics & Concepts
MicrobiologyBiologyBacteriaAntibioticsGastrointestinal tractAntibiotic resistanceGeneticsBiochemistryAntibiotic Resistance in BacteriaClostridium difficile and Clostridium perfringens researchVibrio bacteria research studies