Nickel-catalysed enantioselective reaction of secondary phosphine oxides and activated vinylcyclopropanes
Zhuo Huang, Xu-Teng Liu, Ranran Cui, Qing‐Wei Zhang
Abstract
Activated vinylcyclopropanes can form zwitterionic π-allylmetal species in the presence of transition metals and are widely used in organic synthesis. A nickel-catalyzed asymmetric allylation of secondary phosphine oxides with vinylcyclopropanes was described. Tertiary phosphine oxide products could be obtained with up to 91% yield and 92% ee.
Topics & Concepts
PhosphineNickelEnantioselective synthesisYield (engineering)Phosphine oxideChemistryCatalysisTransition metalOxideNickel oxideOrganic chemistryMaterials scienceMetallurgyCyclopropane Reaction MechanismsAsymmetric Hydrogenation and CatalysisAsymmetric Synthesis and Catalysis