Surface Membrane Coating as a Versatile Platform for Modifying Antitumor Nanoparticles
Qìng Yu, Wenzhe Wang, Haixia Ji, Luyao Tian, Mingjuan Yang, Juan Wang, Xia Li, Luqi Huang, Lanping Guo, Wenyuan Gao
Abstract
Antitumor nanoparticles now confront several obstacles, including poor biocompatibility and biodegradability, quick removal, and a short cycle time, given the growing interest in surface membrane coating as a versatile platform for altering nanoparticles and overcoming the limitations of current nanodrug delivery methods. This paper reviews the recent progress of cells, synthetic polymers, polyphenols, and polysaccharides membrane coatings with favorable biocompatibility and biodegradability and easy surface modification on the surface of antitumor nanoparticle platforms, which can provide a promising strategy for endowing nanoparticles with specific and expected performance to optimize the efficiency of antitumor. Furthermore, multiple membrane combination strategies and additional biorecognition ligands modification on the membrane surface are supplied in an attempt to tackle the challenges of single membrane coating in a variety of tumor therapeutic applications and ultimately facilitate effective clinical transformation.