Enoyl coenzyme A hydratase 1 alleviates nonalcoholic steatohepatitis in mice by suppressing hepatic ferroptosis
Bing Liu, Wei Yi, Xiaoxiang Mao, Ling Yang, Caijun Rao
Abstract
Enoyl coenzyme A hydratase 1 (ECH1) is a key component in mitochondrial fatty acid β-oxidation and is also a well-known enzyme for lipid metabolism. However, the biological role of ECH1 in the development of NASH is still unclear. Herein, we demonstrated that ECH1 inhibits NASH by inhibiting ferroptosis, thus providing a novel target for therapeutic intervention for future treatment of NASH.
Topics & Concepts
Nonalcoholic steatohepatitisSteatohepatitisSteatosisChemistryLiver injuryMedicineBiochemistryPharmacologyInternal medicineFatty liverNonalcoholic fatty liver diseaseDiseaseFerroptosis and cancer prognosisMicroRNA in disease regulationDrug Transport and Resistance Mechanisms