Next generation risk assessment (NGRA): Bridging in vitro points-of-departure to human safety assessment using physiologically-based kinetic (PBK) modelling – A case study of doxorubicin with dose metrics considerations
Hequn Li, Haitao Yuan, A. Middleton, Jin Li, Beate Nicol, Paul L. Carmichael, Jiabin Guo, Shuangqing Peng, Qiang Zhang
Topics & Concepts
CardiotoxicityPharmacologyRisk assessmentCmaxDoxorubicinIn vitroPharmacokineticsDosingHuman healthToxicityPopulationChemistryMedicineComputer scienceBiochemistryInternal medicineChemotherapyEnvironmental healthComputer securityChemotherapy-induced cardiotoxicity and mitigationPolymer Nanocomposite Synthesis and IrradiationRadiation Effects in Electronics